If youre talking about the Internet Explorer home page, then sure! Thats User Configuration | Windows Settings | Internet Explorer Maintenance | URLs | Home Page URL.
While youre there, check out Administrative Templates | Windows Components | Internet Explorer | Disable changing home page settings. This ensures that users cannot change it once youve set it.
If youd like to do this in Firefox or Chrome, youll need PolicyPak (www.PolicyPak.com) to do it.