The last sentence is a little confusing. But this is what I see from the first half. The GPO with the user settings as well as the loopback setting need to be set on the OU that the computers in question are in, not the location OU. Right now you state that they are in the Computers container and GPO's cannot be assigned to a container. You will need to create a new OU for the computers that these setting will apply and link the GPOs and set loopback there. This way ANY user from any OU, if they are logging into one of these computers will get those user settings. And they will ONLY apply when logging into those specific computers. No filtering is necessary.
I hope this makes sense.
Scott


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