It would be hard to tell exactly what is happening with this, since its intermittent and only an error provided.
Is GPMC being run from a workstation or a domain controller? Maybe if your running it from a workstation, we could be querying for a DC that has been removed from the network, but not cleaned out of Active Directory. Eventually, you may be querying for a good DC. hence the intermittent problem.
Just a guess. You might take a network trace when you load the GPMC, and monitor the DNS queries. Which DC are we looking for? Is the resulting DC online? RPC started? Does the name resolve to the correct IP?
Just some thoughts.
-cp


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