If these 50 GPOs apply to users/machines all at once, this is starting to be a big load.
If only a handful apply to any given situation, this is less of a problem.
As long as they don't change too often they don't generate replication traffic so no really big shakes there.
Number of settings per GPO will be a bigger factor in speed issues and load on both server delivering the GP and on workstations processing them. Inheritance complexity (blocking / overriding) will increase this effort as well.
One thing you don't mention is your domain model - is this a single domain with many sites or are there several here? If more than one, you need to ensure that policies are applied correctly so that a site will get policies from a local DC - avoid cross-domain links if at all possible.


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