I'm assuming that the students will be logging in as "Users" without any kind of admin rights.
If you are running MS Office, MS has ADMX files you can install to your domain to control settings for Office via GPO. In particular, there are browser settings for web-enabled office documents that need to be set in addition to the normal IE security settings.
MS has a free tool "Microsoft Security Compliance Manger" and a set of baseline GPO policies that are good starting points for building from 'scratch'. If you want maximum lockdown, look at the SSLF (specialized security - limited functionality) baseline policies.
You may want to consider using applocker to prevent users from installing Firefox or Google Chrome, (assuming you do not have these browsers already installed). Both of those browsers can be installed by "users" without admin rights. I'm not sure what you mean by "desktop" locked down. You can also remove their ability to get to the personalization and desktop properties so they can't change themes, oh, and disable widget installation. Check IE settings, in particular RSS/Web Slice feeds (they are a security risk).
Just remember, being locked down, you will need to spend more time supporting the machines. You will probably want to deploy printers and perhaps install plug-ins, etc. via GPO.


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